The latest release of FeedDemon now features deep integration with Google Reader. Amit Agarwal has more:

FeedDemon 3 can automatically sync your feeds, items tags and shared items with Google Reader. In simple English, it means that if you read a feed inside Google Reader, it won’t show up as “unread” in FeedDemon and vice-versa. Similarly, if you attach a tag or text note to some item in Google Reader, it would appear in FeedDemon as well.

I’ve used the beta version of FeedDemon 3; some might find it better than the Google Reader website: better use of screen space, pre-fetching for offline use, Twitter integration.